The piperazine salts are used for the treatment of ascarids in dogs, cats and poultry. Piperazine Kyron is a white crystalline powder consisting of I 00% piperazine adipate (=37% piperazine base). Piperazine acts by altering muscular polarisation in susceptible nematodes, thereby paralysing the worm and allowing it to be passed out with the faeces. This neuromuscular effect is believed to be caused by blocking acetylcholine at the myoneural junction. In ascarids, succinic acid production is also inhibited. Piperazine adipate is readily absorbed from the proximal sections of the GI tract and the drug is metabolised and excreted by the kidneys. Piperazine compounds have a wide margin of safety in all animals.
Indications
Dogs & Cats
Round Worms (Toxocara and toxoscaris Spp.)
Poultry
Round Worms (Ascaridis galli, Capillaria Spp.)
Dosage
Dogs & Cats: 1.25 to 1.5 g per 10 kg body weight.
Poultry:
Adult Birds: 15 g for 30 adult birds (0.5 g/kg bw)*.
Below 6 weeks: 15g for 60 birds (0.25 g/kg bw) in feed or drinking water.
When infestation with Capillaria species is suspected double the recommended dose.
*Dosing tips: If a 1kg bird eats/drinks:
- 50 g of food, the dose is 10 g/ 1kg feed
- 160 ml of water, the dose is 10 g/ 3 L water.
Withdrawal Periods
- Meat withdrawal period: 8 days
- Eggs withdrawal period: 4 days
Storage
Store in a cool (not more than 25° C ), dry place
